Gene information
Official symbol PLA2G1B
Official full name phospholipase A2 group IB
Gene type protein-coding gene
Chromosome12q24.31
Previous symbolPLA2; PPLA2; PLA2A
Gene familyPhospholipases
Resources
Entrez Gene 5319
HGNC HGNC:9030
Ensembl ENSG00000170890
Vega OTTHUMG00000169343
UCSC uc001tyd.3
GO terms: 100 records
GO Description Category LogP Number of genes Detail
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0002252 immune effector process GO Biological Processes -24.2648770 43 More
GO:0002443 leukocyte mediated immunity GO Biological Processes -15.2263375 27 More
GO:0002444 myeloid leukocyte mediated immunity GO Biological Processes -7.71730059 9 More
GO:0002446 neutrophil mediated immunity GO Biological Processes -8.04833674 7 More
GO:0005509 calcium ion binding GO Molecular Functions -14.7764642 80 More
GO:0006644 phospholipid metabolic process GO Biological Processes -2.96272379 13 More
GO:0006650 glycerophospholipid metabolic process GO Biological Processes -2.76007072 11 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0006959 humoral immune response GO Biological Processes -20.5068158 33 More
GO:0007204 positive regulation of cytosolic calcium ion concentration GO Biological Processes -15.6883547 39 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0010827 regulation of glucose transmembrane transport GO Biological Processes -18.4601079 28 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0010959 regulation of metal ion transport GO Biological Processes -23.6318171 71 More
GO:0015908 fatty acid transport GO Biological Processes -7.46702847 10 More
GO:0015909 long-chain fatty acid transport GO Biological Processes -7.56395612 9 More
GO:0016788 hydrolase activity, acting on ester bonds GO Molecular Functions -4.57583420 56 More
GO:0019730 antimicrobial humoral response GO Biological Processes -11.7829906 16 More
GO:0030029 actin filament-based process GO Biological Processes -9.62516039 61 More
GO:0030036 actin cytoskeleton organization GO Biological Processes -5.67075265 47 More
GO:0030593 neutrophil chemotaxis GO Biological Processes -16.9449855 18 More
GO:0030595 leukocyte chemotaxis GO Biological Processes -30.6401488 33 More
GO:0031406 carboxylic acid binding GO Molecular Functions -5.96500660 23 More
GO:0032309 icosanoid secretion GO Biological Processes -4.62385244 5 More
GO:0032677 regulation of interleukin-8 production GO Biological Processes -20.0046302 33 More
GO:0032757 positive regulation of interleukin-8 production GO Biological Processes -14.6396218 15 More
GO:0032868 response to insulin GO Biological Processes -11.6850377 35 More
GO:0032869 cellular response to insulin stimulus GO Biological Processes -9.16399556 26 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0033293 monocarboxylic acid binding GO Molecular Functions -4.50166323 13 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034764 positive regulation of transmembrane transport GO Biological Processes -18.2616571 46 More
GO:0034765 regulation of ion transmembrane transport GO Biological Processes -18.4305966 71 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0042742 defense response to bacterium GO Biological Processes -25.9215771 41 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043405 regulation of MAP kinase activity GO Biological Processes -18.9267681 42 More
GO:0043406 positive regulation of MAP kinase activity GO Biological Processes -13.8261343 18 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043434 response to peptide hormone GO Biological Processes -26.1739008 69 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045860 positive regulation of protein kinase activity GO Biological Processes -29.3929160 47 More
GO:0046324 regulation of glucose import GO Biological Processes -14.8736114 22 More
GO:0046470 phosphatidylcholine metabolic process GO Biological Processes -5.57583811 8 More
GO:0046486 glycerolipid metabolic process GO Biological Processes -5.86759713 18 More
GO:0046903 secretion GO Biological Processes -18.5147167 70 More
GO:0048145 regulation of fibroblast proliferation GO Biological Processes -11.1167439 21 More
GO:0048146 positive regulation of fibroblast proliferation GO Biological Processes -7.96091962 9 More
GO:0050482 arachidonic acid secretion GO Biological Processes -3.60377864 4 More
GO:0050708 regulation of protein secretion GO Biological Processes -30.3716714 63 More
GO:0050714 positive regulation of protein secretion GO Biological Processes -15.7339081 32 More
GO:0050778 positive regulation of immune response GO Biological Processes -17.2528761 40 More
GO:0050830 defense response to Gram-positive bacterium GO Biological Processes -13.1972375 17 More
GO:0050900 leukocyte migration GO Biological Processes -39.9164759 46 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051047 positive regulation of secretion GO Biological Processes -32.2282376 71 More
GO:0051090 regulation of DNA-binding transcription factor activity GO Biological Processes -25.8933515 78 More
GO:0051091 positive regulation of DNA-binding transcription factor activity GO Biological Processes -17.7436786 49 More
GO:0051092 positive regulation of NF-kappaB transcription factor activity GO Biological Processes -14.8614421 21 More
GO:0051222 positive regulation of protein transport GO Biological Processes -13.8994291 46 More
GO:0051223 regulation of protein transport GO Biological Processes -25.2801266 81 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051924 regulation of calcium ion transport GO Biological Processes -18.2498286 49 More
GO:0051928 positive regulation of calcium ion transport GO Biological Processes -8.94961635 14 More
GO:0060326 cell chemotaxis GO Biological Processes -35.3882493 41 More
GO:0060341 regulation of cellular localization GO Biological Processes -10.5933083 72 More
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide GO Biological Processes -7.52692728 10 More
GO:0070201 regulation of establishment of protein localization GO Biological Processes -24.4831554 82 More
GO:0071375 cellular response to peptide hormone stimulus GO Biological Processes -15.9961580 44 More
GO:0071417 cellular response to organonitrogen compound GO Biological Processes -26.3253267 90 More
GO:0071621 granulocyte chemotaxis GO Biological Processes -16.4324548 18 More
GO:0071715 icosanoid transport GO Biological Processes -4.05681596 5 More
GO:0071900 regulation of protein serine/threonine kinase activity GO Biological Processes -19.5794055 63 More
GO:0071902 positive regulation of protein serine/threonine kinase activity GO Biological Processes -13.5008002 23 More
GO:0097435 supramolecular fiber organization GO Biological Processes -6.48496756 24 More
GO:0097529 myeloid leukocyte migration GO Biological Processes -25.8454617 28 More
GO:0097530 granulocyte migration GO Biological Processes -19.1764933 21 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:1901653 cellular response to peptide GO Biological Processes -21.5212108 58 More
GO:1901699 cellular response to nitrogen compound GO Biological Processes -26.9091664 96 More
GO:1903169 regulation of calcium ion transmembrane transport GO Biological Processes -8.80532519 28 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903532 positive regulation of secretion by cell GO Biological Processes -27.9542102 63 More
GO:1903829 positive regulation of protein localization GO Biological Processes -12.9651258 57 More
GO:1903963 arachidonate transport GO Biological Processes -3.60377864 4 More
GO:1904035 regulation of epithelial cell apoptotic process GO Biological Processes -21.2824424 33 More
GO:1904037 positive regulation of epithelial cell apoptotic process GO Biological Processes -11.2663674 9 More
GO:1904062 regulation of cation transmembrane transport GO Biological Processes -18.6629834 61 More
GO:1904427 positive regulation of calcium ion transmembrane transport GO Biological Processes -4.11465146 13 More
GO:1904951 positive regulation of establishment of protein localization GO Biological Processes -13.0308630 46 More
GO:1990266 neutrophil migration GO Biological Processes -18.6358512 20 More
KEGG pathways: 4 records
KEGG Description Category LogP Number of genes Detail
hsa04014 Ras signaling pathway KEGG Pathway -9.01898803 33 More
hsa04270 Vascular smooth muscle contraction KEGG Pathway -11.6218936 17 More
hsa04972 Pancreatic secretion KEGG Pathway -1.34535762 4 More
hsa04975 Fat digestion and absorption KEGG Pathway -5.93899775 11 More
Drug-Gene interaction
view
Related drugs: 22 records
Drug name Interaction type Source PMID View
adriamycin NCI 2007582 view
alexidine hydrochloride DTC view
amitriptyline NCI 12856820 view
bifonazole DTC view
cetylpyridinium bromide DTC view
chembl528181 DTC view
chembl605084 DTC view
chenodiol DTC 19102680 view
cholic acid DTC 19102680 view
clobetasol TTD view
clocortolone TTD view
contezolid acefosamil TTD view
deoxy cholate DTC 19102680 view
diflorasone TTD view
etoposide NCI 9716508 view
fenticlor DTC view
manoalide TTD view
miltefosine TTD view
progesterone NCI 7872957 view
ranitidine NCI 10383521 view
rilapladib TTD view
tolfenamic acid DTC view
Related studies: 5 records
Molecular factor Omics type Application Objective MI type Reference
PLA2G1B transcriptomics cardiovascular adverse events[prognosis (bad)] acute ST elevation myocardial infarction Takahashi S et al. Int J Cardiol. 2013
phospholipase A2 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Leong LL et al. Clin Exp Pharmacol Physiol. 1992
phospholipase A2 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Langton SR et al. Clin Chim Acta. 1992
phospholipase A2 proteomics cardiovascular death[prognosis (bad)] acute myocardial infarction Porela P et al. Basic Res Cardiol. 2000
phospholipase A2 proteomics heart failure[prognosis (bad)] acute myocardial infarction Arakawa N et al. Cardiology. 2000
All rights reserved: Soochow University Center for Systems Biology